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Relevant Publications

For full list of selected publications, see the publications page

Representational dynamics during extinction of fear memories in the human brain

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Pacheco-Estefan, D., Bouyeure, A., Jacob, G., Fellner, M.-C., Lehongre, K., Lambrecq, V., Frazzini, V., Navarro, V., Güntürkün, O., Shen, L., Yang, J., Han, B., Chen, Q., & Axmacher, N. (2025). Representational dynamics during extinction of fear memories in the human brain. Nature Human Behaviour. https://doi.org/10.1038/s41562-025-02268-5

Reference in memories from perceptual and non-perceptual experiences: a non-disjunctivist account including vicarious, oneiric and fictional remembering

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Werning, M., & Liefke, K. (2025). Reference in memories from perceptual and non-perceptual experiences: a non-disjunctivist account including vicarious, oneiric and fictional remembering. Synthese, 205(5), 186. https://doi.org/10.1007/s11229-025-04936-5

Interindividual Variability in Memory Performance Is Related to Corticothalamic Networks during Memory Encoding and Retrieval

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Passiatore, R., Lupo, A., Sambuco, N., Antonucci, L. A., Stolfa, G., Bertolino, A., Popolizio, T., Suchan, B., & Pergola, G. (2025). Interindividual Variability in Memory Performance Is Related to Corticothalamic Networks during Memory Encoding and Retrieval. The Journal of Neuroscience, 45(19), e0975242025. https://doi.org/10.1523/JNEUROSCI.0975-24.2025

Extinction context is learned by pigeons, not given by the environment

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Peschken, J., Hahn, L. A., Pusch, R., & Rose, J. (2025). Extinction context is learned by pigeons, not given by the environment. Communications Psychology, 3(1), 83. https://doi.org/10.1038/s44271-025-00261-2

Representational dynamics during extinction of fear memories in the human brain

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Pacheco-Estefan, D., Bouyeure, A., Jacob, G., Fellner, M.-C., Lehongre, K., Lambrecq, V., Frazzini, V., Navarro, V., Güntürkün, O., Shen, L., Yang, J., Han, B., Chen, Q., & Axmacher, N. (2025). Representational dynamics during extinction of fear memories in the human brain. Nature Human Behaviour. https://doi.org/10.1038/s41562-025-02268-5

Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence

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Stammen, C., Penate, J. S., Metzen, D., Hönscher, M. J., Fraenz, C., Schlüter, C., Güntürkün, O., Kumsta, R., & Genç, E. (2025). Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence. Cerebral Cortex, 35(7), bhaf199. https://doi.org/10.1093/cercor/bhaf199

The multidimensional profile methodology (MPM) for comparative cognition: towards a universal strategy of understanding animal minds

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Dung, L., & Newen, A. (2025). The multidimensional profile methodology (MPM) for comparative cognition: towards a universal strategy of understanding animal minds. Philosophical Studies. https://doi.org/10.1007/s11098-025-02363-3

Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear

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Labrenz, F., Kalenbach, A., Elsenbruch, S., & Icenhour, A. (2025). Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear. Scientific Reports, 15(1), 27001. https://doi.org/10.1038/s41598-025-10499-9

Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome

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Domschke, K., Schiele, M. A., Crespo Salvador, Ó., Zillich, L., Lipovsek, J., Pittig, A., Heinig, I., Ridderbusch, I. C., Straube, B., Richter, J., Hollandt, M., Plag, J., Fydrich, T., Koelkebeck, K., Weber, H., Lueken, U., Dannlowski, U., Margraf, J., Schneider, S., … Deckert, J. (2025). Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome. Molecular Psychiatry. https://doi.org/10.1038/s41380-025-03038-5

Prior knowledge activation as preparation prior to instruction: does the coverage of relevant prior knowledge affect learning?

18825267 {18825267:T9N28PEX} 1 apa 50 default 6043 https://philosophy-cognition.com/cmc/wp-content/plugins/zotpress/
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Brand, C., Loibl, K., & Rummel, N. (2025). Prior knowledge activation as preparation prior to instruction: does the coverage of relevant prior knowledge affect learning? Instructional Science. https://doi.org/10.1007/s11251-025-09727-6

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Newen, 2023 Dung, L., & Newen, A. (2023). Profiles of animal consciousness: A species-sensitive, two-tier account to quality and distribution. Cognition, 235, 105409. https://doi.org/10.1016/j.cognition.2023.105409

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Peters, Cosentino & Werning, 2022 Peeters, A., Cosentino, E., & Werning, M. (2022). Constructing a wider view on memory – Beyond the dichotomy of field and observer perspectives. In A. Berninger & Í. V. Ferran (eds.), Memory and Imagination (pp. 165–190)....

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Schneider, 2022 Schoppmann, J., Schneider, S., & Seehagen, S. (2022). Can you teach me not to be angry? Relations between temperament and the emotion regulation strategy distraction in 2-year-olds. Child Development, 93(1), 165–179....

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Hennecke, 2023 Hennecke, M., & Bürgler, S.(2023). Metacognition and self-control: An integrative framework. Psychological Review, 130(5), 1262-1268. https://doi.org/10.1037/rev0000406

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Wiskott, 2018 Bayati, M., Neher, T., Melchior, J., Diba, K., Wiskott, L., & Cheng, S. (2018). Storage fidelity for sequence memory in the hippocampal circuit. PloS One, 13(10), e0204685. https://doi.org/10.1371/journal.pone.0204685

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Schöner & Sabinasz, 2023 Sabinasz, D., Richter, M., & Schöner, G. (2023). Neural dynamic foundations of a theory of higher cognition: The case of grounding nested phrases. Cognitive Neurodynamics.  https://doi.org/10.1007/s11571-023-10007-7

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Weber-Guskar, 2021 Weber-Guskar, E. (2021). Drohen mit dem Einsatz von Künstlicher Intelligenz neue Menschenwürdeverletzungen? In R. Kipke, N. Röttger, J. Wagner, & A. K. v. Wedelstaedt (Hrsg.), ZusammenDenken: Festschrift für Ralf Stoecker (S. 227–247). Springer...

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