Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence
18825267
{18825267:HEZKSS8T}
1
apa
50
default
6047
https://philosophy-cognition.com/cmc/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22HEZKSS8T%22%2C%22library%22%3A%7B%22id%22%3A18825267%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Stammen%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BStammen%2C%20C.%2C%20Penate%2C%20J.%20S.%2C%20Metzen%2C%20D.%2C%20H%26%23xF6%3Bnscher%2C%20M.%20J.%2C%20Fraenz%2C%20C.%2C%20Schl%26%23xFC%3Bter%2C%20C.%2C%20G%26%23xFC%3Bnt%26%23xFC%3Brk%26%23xFC%3Bn%2C%20O.%2C%20Kumsta%2C%20R.%2C%20%26amp%3B%20Gen%26%23xE7%3B%2C%20E.%20%282025%29.%20Neurite%20density%20but%20not%20myelination%20of%20specific%20fiber%20tracts%20links%20polygenic%20scores%20to%20general%20intelligence.%20%26lt%3Bi%26gt%3BCerebral%20Cortex%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B35%26lt%3B%5C%2Fi%26gt%3B%287%29%2C%20bhaf199.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcercor%5C%2Fbhaf199%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcercor%5C%2Fbhaf199%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Neurite%20density%20but%20not%20myelination%20of%20specific%20fiber%20tracts%20links%20polygenic%20scores%20to%20general%20intelligence%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christina%22%2C%22lastName%22%3A%22Stammen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Javier%20Schneider%22%2C%22lastName%22%3A%22Penate%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dorothea%22%2C%22lastName%22%3A%22Metzen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maurice%20J%22%2C%22lastName%22%3A%22H%5Cu00f6nscher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christoph%22%2C%22lastName%22%3A%22Fraenz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caroline%22%2C%22lastName%22%3A%22Schl%5Cu00fcter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Onur%22%2C%22lastName%22%3A%22G%5Cu00fcnt%5Cu00fcrk%5Cu00fcn%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Robert%22%2C%22lastName%22%3A%22Kumsta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erhan%22%2C%22lastName%22%3A%22Gen%5Cu00e7%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20White%20matter%20is%20fundamental%20for%20efficient%20information%20transfer%20and%20thus%20crucial%20for%20intelligence.%20Previous%20studies%20demonstrated%20associations%20between%20fractional%20anisotropy%20and%20intelligence%2C%20but%20it%20remains%20unclear%20whether%20this%20relation%20is%20due%20to%20greater%20axon%20density%2C%20parallel%2C%20homogenous%20fiber%20orientation%20distributions%2C%20or%20greater%20myelination%2C%20as%20all%20influence%20fractional%20anisotropy.%20Using%20neurite%20orientation%20dispersion%20and%20density%20imaging%20and%20myelin%20water%20fraction%20imaging%2C%20we%20analyzed%20the%20microstructural%20architecture%20of%20intelligence%20in%20500%20healthy%20young%20adults.%20We%20were%20also%20interested%20whether%20specific%20white%20matter%20indices%20mediate%20the%20pathway%20linking%20genetic%20disposition%20for%20intelligence%20to%20phenotype.%20For%20the%20first%20time%2C%20we%20conducted%20mediation%20analyses%20investigating%20whether%20neurite%20density%20index%2C%20orientation%20dispersion%20index%2C%20and%20myelin%20water%20fraction%20of%2064%20white%20matter%20tracts%20mediate%20the%20effects%20of%20polygenic%20scores%20for%20intelligence%20on%20general%20intelligence%20%28g%29.%20Our%20results%20showed%20that%20neurite%20density%20index%2C%20but%20not%20orientation%20dispersion%20index%20or%20myelin%20water%20fraction%20of%20white%20matter%20tracts%2C%20was%20significantly%20associated%20with%20g%20and%20that%20neurite%20density%20index%20of%20six%20fiber%20tracts%20mediated%20the%20relation%20between%20genetic%20variability%20and%20g.%20These%20findings%20are%20a%20crucial%20step%20toward%20decoding%20the%20neurogenetic%20underpinnings%20of%20general%20intelligence%2C%20as%20they%20identify%20that%20neurite%20density%20of%20specific%20fiber%20tracts%20relates%20polygenic%20variation%20to%20g%2C%20whereas%20orientation%20dispersion%20and%20myelination%20did%20not.%22%2C%22date%22%3A%222025-07-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fcercor%5C%2Fbhaf199%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Facademic.oup.com%5C%2Fcercor%5C%2Farticle%5C%2Fdoi%5C%2F10.1093%5C%2Fcercor%5C%2Fbhaf199%5C%2F8216885%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221047-3211%2C%201460-2199%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%222ADRQ6UB%22%5D%2C%22dateModified%22%3A%222025-11-12T13%3A04%3A09Z%22%7D%7D%5D%7D
Stammen, C., Penate, J. S., Metzen, D., Hönscher, M. J., Fraenz, C., Schlüter, C., Güntürkün, O., Kumsta, R., & Genç, E. (2025). Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence. Cerebral Cortex, 35(7), bhaf199. https://doi.org/10.1093/cercor/bhaf199