18825267 {18825267:IKXUVIP3} 1 apa 50 default 6045 https://philosophy-cognition.com/cmc/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22IKXUVIP3%22%2C%22library%22%3A%7B%22id%22%3A18825267%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lissek%20and%20Tegenthoff%22%2C%22parsedDate%22%3A%222025-07-03%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLissek%2C%20S.%2C%20%26amp%3B%20Tegenthoff%2C%20M.%20%282025%29.%20Regional%20prefrontal%20and%20hippocampal%20differences%20in%20gray%20matter%20volume%20are%20linked%20to%20the%20propensity%20for%20renewal%20in%20extinction%20learning.%20%26lt%3Bi%26gt%3BFrontiers%20in%20Behavioral%20Neuroscience%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B19%26lt%3B%5C%2Fi%26gt%3B%2C%201592929.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffnbeh.2025.1592929%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffnbeh.2025.1592929%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Regional%20prefrontal%20and%20hippocampal%20differences%20in%20gray%20matter%20volume%20are%20linked%20to%20the%20propensity%20for%20renewal%20in%20extinction%20learning%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Silke%22%2C%22lastName%22%3A%22Lissek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Tegenthoff%22%7D%5D%2C%22abstractNote%22%3A%22Introduction%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20renewal%20effect%20of%20extinction%20describes%20the%20reoccurrence%20of%20an%20extinguished%20response%20if%20recall%20is%20performed%20in%20a%20context%20that%20is%20not%20the%20same%20as%20the%20extinction%20context.%20This%20learning%20phenomenon%20is%20clinically%20relevant%2C%20since%20it%20potentially%20interferes%20with%20therapy%20success%20for%20anxiety%20disorders%20or%20phobias.%20The%20propensity%20to%20show%20the%20renewal%20effect%20appears%20to%20be%20a%20stable%20processing%20strategy%20in%20context-related%20extinction%2C%20associated%20with%20higher%20BOLD%20activation%20in%20hippocampus%2C%20ventromedial%20PFC%20%28vmPFC%29%20and%20inferior%20frontal%20gyrus%20%28IFG%29%20in%20individuals%20who%20show%20renewal%20%28REN%29%20compared%20to%20those%20who%20do%20not%20%28NoREN%29.%20However%2C%20evidence%20on%20a%20potential%20relationship%20between%20structural%20properties%20such%20as%20gray%20matter%20volume%20%28GMV%29%20in%20these%20regions%20and%20the%20propensity%20to%20show%20renewal%20is%20lacking.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20this%20study%2C%20we%20applied%20voxel-based%20morphometry%20%28VBM%29%20to%20investigate%20whether%20individuals%20with%20and%20without%20a%20propensity%20for%20renewal%20differ%20regarding%20their%20GMV%20in%20extinction-related%20brain%20regions%2C%20and%20whether%20such%20a%20difference%20is%20linked%20to%20the%20renewal%20level.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%20revealed%20differential%20GMV%20in%20REN%20and%20NoREN%20in%20adjacent%20subregions%20of%20IFG%20and%20vmPFC%2C%20respectively.%20Higher%20GMV%20in%20REN%20was%20located%20predominantly%20in%20orbital%20IFG%20and%20in%20BA10%20of%20vmPFC.%20Higher%20GMV%20in%20NoREN%20was%20located%20predominantly%20in%20triangular%20IFG%20and%20in%20BA%2011%20of%20vmPFC.%20In%20bilateral%20anterior%20cingulate%20cortex%20%28ACC%29%20and%20anterior%20hippocampus%2C%20GMV%20was%20overall%20higher%20in%20NoREN.%20In%20the%20complete%20sample%2C%20higher%20GMV%20in%20IFG%20BA%2047%2C%20vmPFC%20BA11%2C%20bilateral%20ACC%20and%20bilateral%20anterior%20hippocampus%20was%20associated%20with%20less%20renewal%2C%20and%20partially%20with%20a%20higher%20error%20level%20in%20extinction%20learning%20in%20a%20novel%20context.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Discussion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20findings%20suggest%20that%20higher%20GMV%20in%20several%20regions%20active%20during%20extinction%20learning%20may%20support%20a%20more%20thorough%20processing%20of%20extinction%20trials%20which%20in%20turn%20could%20be%20conducive%20to%20an%20extinction%20recall%20solely%20based%20on%20recent%20extinction%20memory%2C%20disregarding%20context%20information.%20In%20summary%2C%20this%20study%20provides%20first-time%20evidence%20for%20a%20relationship%20of%20GMV%20in%20of%20extinction-%20and%20renewal-relevant%20brain%20regions%20with%20behavioral%20performance%20during%20extinction%20learning%20and%20the%20propensity%20to%20show%20the%20renewal%20effect.%22%2C%22date%22%3A%222025-7-3%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffnbeh.2025.1592929%22%2C%22ISSN%22%3A%221662-5153%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.frontiersin.org%5C%2Farticles%5C%2F10.3389%5C%2Ffnbeh.2025.1592929%5C%2Ffull%22%2C%22collections%22%3A%5B%222ADRQ6UB%22%5D%2C%22dateModified%22%3A%222025-11-12T13%3A04%3A15Z%22%7D%7D%5D%7D
Lissek, S., & Tegenthoff, M. (2025). Regional prefrontal and hippocampal differences in gray matter volume are linked to the propensity for renewal in extinction learning. Frontiers in Behavioral Neuroscience, 19, 1592929. https://doi.org/10.3389/fnbeh.2025.1592929