18825267
{18825267:MUNRQGPX}
1
apa
50
default
6037
https://philosophy-cognition.com/cmc/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22MUNRQGPX%22%2C%22library%22%3A%7B%22id%22%3A18825267%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Labrenz%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-24%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLabrenz%2C%20F.%2C%20Kalenbach%2C%20A.%2C%20Elsenbruch%2C%20S.%2C%20%26amp%3B%20Icenhour%2C%20A.%20%282025%29.%20Costly%20pain%20avoidance%20and%20its%20impact%20on%20the%20modulation%20and%20extinction%20of%20visceral%20pain-related%20fear.%20%26lt%3Bi%26gt%3BScientific%20Reports%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B15%26lt%3B%5C%2Fi%26gt%3B%281%29%2C%2027001.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-10499-9%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-025-10499-9%26lt%3B%5C%2Fa%26gt%3B%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Costly%20pain%20avoidance%20and%20its%20impact%20on%20the%20modulation%20and%20extinction%20of%20visceral%20pain-related%20fear%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22Labrenz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Kalenbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sigrid%22%2C%22lastName%22%3A%22Elsenbruch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Adriane%22%2C%22lastName%22%3A%22Icenhour%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Along%20the%20gut-brain%20axis%2C%20visceral%20pain%20demonstrably%20evokes%20emotional%20learning%20and%20memory%20processes%20shaping%20behavior%20in%20clinically%20relevant%20ways.%20Avoidance%20motivated%20by%20learned%20fear%20may%20constitute%20a%20major%20obstacle%20to%20treatment%20success%20in%20extinction-based%20interventions.%20However%2C%20the%20effects%20of%20avoidance%20on%20visceral%20pain-related%20fear%20extinction%20remain%20poorly%20understood.%20By%20implementing%20an%20ecologically%20valid%20experimental%20protocol%2C%20we%20investigated%20how%20costly%20avoidance%20affects%20the%20modulation%20and%20extinction%20of%20visceral%20pain-related%20fear.%20Thirty-three%20healthy%20volunteers%20underwent%20conditioning%20with%20visual%20cues%20%28conditioned%20stimuli%3B%20CS%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2CCS%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%5Cu2212%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%29%20consistently%20followed%20by%20visceral%20pain%20or%20remaining%20unpaired.%20During%20avoidance%2C%20participants%20decided%20to%20avoid%20or%20receive%20pain%20upon%20confronting%20CS%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20.%20Avoidance%20decisions%20resulted%20in%20pain%20omission%20in%20some%20trials%2C%20while%20in%20others%2C%20participants%20experienced%20unpredictable%20pain.%20During%20extinction%2C%20CS%20were%20presented%20unpaired.%20CS%20valence%2C%20fear%2C%20and%20trial-by-trial%20decisions%20were%20analyzed.%20Avoidance%20decisions%20depended%20on%20prior%20experiences%2C%20with%20the%20highest%20probability%20of%20avoidance%20following%20successful%20pain%20omission.%20Negative%20CS%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20valence%20and%20fear%20remained%20elevated%20across%20avoidance%20and%20extinction.%20Learned%20fear%20and%20more%20avoidance%20decisions%20explained%2057%25%20variance%20in%20sustained%20CS%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20%2B%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20fear.%20Our%20findings%20indicate%20that%20avoidance%2C%20which%20provides%20short-term%20absence%20of%20pain%20even%20when%20followed%20by%20unpredictable%20pain%2C%20motivates%20its%20maintenance.%20However%2C%20it%20perpetuates%20pain-related%20fear%20and%20may%20impede%20extinction%2C%20with%20implications%20for%20persisting%20symptoms%20and%20therapeutic%20outcomes%20in%20chronic%20visceral%20pain.%22%2C%22date%22%3A%222025-07-24%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-025-10499-9%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-025-10499-9%22%2C%22collections%22%3A%5B%222ADRQ6UB%22%5D%2C%22dateModified%22%3A%222025-11-12T13%3A04%3A04Z%22%7D%7D%5D%7D
Labrenz, F., Kalenbach, A., Elsenbruch, S., & Icenhour, A. (2025). Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear. Scientific Reports, 15(1), 27001. https://doi.org/10.1038/s41598-025-10499-9